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Treatment with iptacopan reduces proteinuria in interim APPLAUSE-IgAN analysis
by
Kristen Monaco, Senior Staff Writer, MedPage Today
October 26, 2024
SAN DIEGO — There was a clinically meaningful reduction in proteinuria with iptacopan (Fabhalta), and a confirmed clinical benefit of alternative pathway inhibition, in a rare kidney disorder, according to an interim analysis of the APPLAUSE-IgAN study.
In the phase III study, among the first 250 patients with IgA nephropathy who underwent randomization, the adjusted geometric mean 24-hour urinary protein-to-creatinine ratio (UPCR) was 38.3% (95% CI 26.0-48.6, two-sided P
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